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CEP-32496
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CEP-32496图片
CAS NO:1188910-76-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
CEP32496, CEP 32496, AC013773, AC 013773, AC-013773
产品介绍

生物活性

CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1(B-raf)丝氨酸/苏氨酸蛋白激酶抑制剂,具有潜在的抗肿瘤活性。

Targets

TargetValue
c-KitKd2nM
LCKKd2nM
PDGFRβKd2nM
RETKd2nM
Abl1Kd3nM
VEGFR2Kd8nM
CSF-1RKd9nM
B-Raf(V600E)Kd14nM
EphA2Kd14nM
EGFRKd22nM
B-RafKd36nM
C-RafKd39nM
c-MetKd513nM
JAK2Kd4.7μM
MEK1Kd7.1μM
MEK2Kd8.3μM
JAK1Kd>10μM
JAK3Kd>10μM
ALKKd>10μM
AuroraAKd>10μM
AuroraBKd>10μM
ERK1Kd>10μM
ERK2Kd>10μM
IGF-1RKd>10μM
INSRKd>10μM
PIK3-CAKd>10μM
PIK3-CBKd>10μM
PLK1Kd>10μM

化学数据

目录号A13772
作用机制Inhibitor (抑制剂)
M. Wt553.92
FormulaC24H23ClF3N5O5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1188910-76-0
SynonymsCEP32496, CEP 32496, AC013773, AC 013773, AC-013773
SMILESCC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F

溶解度

In vitro (25°C)DMSO8 mg/mL (15.46 mM)
WaterInsoluble
EthanolInsoluble
In vivo15% Captisol14 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.05 mL90.27 mL180.53 mL
0.5 mM3.61 mL18.05 mL36.11 mL
1 mM1.81 mL9.03 mL18.05 mL
5 mM0.36 mL1.81 mL3.61 mL

*The above data is based on the productmolecular weight 553.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.