CAS NO: | 66611-38-9 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Molecular Weight (MW) | 351.27 |
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Formula | C14H24Cl2N4O2 |
CAS No. | 66611-37-8 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 11.33 mg/mL |
Water: N/A | |
Ethanol: N/A | |
Other info | Chemical Name: N-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide SMILES Code: N=C(NOCC(O)CN1CCCCC1)C2=CN=CC=C2 |
Synonyms | BGP15; BGP-15; BGP 15; BGP15 hydrochloride; BGP15 HCl; N-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide dihydrochloride |
In Vitro | In vitro activity: BGP-15 (200 μM) prevents the imatinib mesylate-induced oxidative damages, attenuates the depletion of high-energy phosphates, alters the signaling effect of imatinib mesylate by preventing p38 MAP kinase and JNK activation, and induced the phosphorylation of Akt and GSK-3beta. Cell Assay: Previous study showed that BGP-15 at 200 μM could prevent the imatinib-induced oxidative damages, attenuate the depletion of high-energy phosphates, alter the signaling effect of imatinib by preventing p38 MAP kinase and JNK activation, and also induce the Akt and GSK-3β phosphorylation. |
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In Vivo | BGP-15 (15 mg/kg, p.o.) does not improve skeletal muscle pathology in older mdx mice. In a rat model, 10 days of BGP-15 treatment greatly improves diaphragm muscle fiber function (by about 100%), although it does not reverse diaphragm atrophy. The treatment also provides protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content. BGP-15 (15 mg/kg per day in saline) treatment has no effect in Ntg mice or an independent cohort of normal adult wild-type mice based on morphology, cardiac function and ECG parameters. Treatment with BGP-15 attenuates the increase in atrial size and lung weight. BGP-15 treatment is able to prevent or reduce episodes of arrhythmia. BGP-15 treatment is associated with a reduced PR interval in the HF+AF model. |
Animal model | Mice |
Formulation & Dosage | 15 mg/kg, p.o. |
References | Am J Pathol. 2016 Dec;186(12):3246-3260; Sci Transl Med. 2016 Aug 3;8(350):350ra103; Nat Commun. 2014 Dec 9;5:5705. |