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Sotalol HCl(MJ 1999)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sotalol HCl(MJ 1999)图片
CAS NO:959-24-0
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)308.82
FormulaC12H20N2O3S.HCl
CAS No.959-24-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 62 mg/mL (200.8 mM)
Water: 62 mg/mL (200.8 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride

InChi Key: VIDRYROWYFWGSY-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

SMILES Code: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl

SynonymsMJ 1999; sotalol Hydrochloride; Sotalol Monohydrochloride; Sotalol HCL; Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob
实验参考方法
In Vitro

In vitro activity: Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassium channels with an IC50 value of ~1.2mM in HEK cell lines.

In VivoIn vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing.
Animal model
Formulation & Dosage
References

J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.