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Acebutolol HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acebutolol HCl图片
CAS NO:34381-68-5
规格:≥98%
包装与价格:
包装价格(元)
2g电议
5g电议
10g电议
25g电议
50g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)372.89
FormulaC18H28N2O4.HCl
CAS No.34381-68-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 75 mg/mL (201.1 mM)
Water:
Ethanol: 75 mg/mL (201.1 mM)
Solubility (In vivo)Saline: 30 mg/mL
SynonymsAcebutolol HCl; Acetobutolol; Neptal; Prent; Sectral; Dl-Acebutolol.
实验参考方法
In Vitro

In vitro activity: Acebutolol inhibits NA uptake in rat brain P2 fractions with IC50 of 0.25 mM. Acebutolol produces a concentration-dependent inhibition of 125I-labeled CYP binding to human fat cell membranes and are able to completely displace all specifically bound radioligand. Acebutolol totally inhibits lipolytic activity initiated by 1 μM isoproterenol. Acebutolol is a cardioselective antagonist possessing low lipid solubility. Acebutolol, which does not bind to LDL, shows a stronger inhibiting effect on the intracellular accumulation of cholesterol esters in J774 macrophages than alprenolol and oxprenolol which bind to LDL.

In VivoAcebutolol following single intravenous administration (10 mg/kg) to rat results in the plasma clearance of 61.9 mL/min/kg, the volume of distribution of 9.6 L/kg, and an elimination half-life of 1.8 hours. Acebutolol following single intravenous administration (50 mg/kg) to rat results in the plasma clearance of 46.5 mL/min/kg, the volume of distribution of 9.5 L/kg, and an elimination half-life of 2.3 hours. Acebutolol (30 mg/kg) decreases cardiac output by 65% and 31% after 1 min and 10 min measurements, respectively, in Sprague-Dawley rats. Acebutolol (30 mg/kg) significantly reduces regional blood flow (RBF) in most organs either after 1 min or 10 min measurements when compare with the baseline values in Sprague-Dawley rats.
Animal modelSprague–Dawley rats
Formulation & DosageDissolved in saline; 10 mg/kg; i.v. injection
References

J Lipid Res. 1988 May;29(5):587-601; Biopharm Drug Dispos. 1997 Aug;18(6):543-56.