Regorafénib N-oxyde M2 is a major and active metabolite of Regorafenib. Regorafenib (also known as BAY 73-4506) is a multi-kinase inhibitor which targets VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 values of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. It is an orally bioavailable small molecule that has anticancer activity and has been approved by FDA for the treatment of liver cancer.

纯度：≥98%

CAS：835621-11-9