Etomoxir is a novel, potent and irreversible (covalent) inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face
of the inner mitochondrial membrane. It inhibits β-oxidation in
mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous
fatty acid in H9c2 cells. Etomoxir has also been identified as a direct
agonist of PPARα. Etomoxir is a compound that binds irreversibly to the
catalytic site of CPT-1 inhibiting its activity, but also upregulates
fatty acid oxidation enzymes.
纯度:≥98%
CAS:124083-20-1