生物活性

Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. Hydralazine (Apresoline) is used to treat high blood pressure. Hydralazine hydrochloride works by relaxing the blood vessels so that blood can flow more easily through the body. Hydralazine hydrochloride increases guanosine monophosphate levels, decreasing the action of the second messenger IP3, limiting calcium release from the sarcoplasmic reticulum of smooth muscle. This results in vessel relaxation. Hydralazine hydrochloride dilates arterioles more than veins. Hydralazine hydrochloride recently has been identified as a nitric oxide donor. Activation of hypoxia-inducible factors has been suggested as a mechanism. Hydralazine hydrochloride relaxes vascular smooth muscles of arteries and arterioles, causing peripheral vasodilation and decreasing peripheral vascular resistance. These actions decrease blood pressure and increase heart rate, stroke volume, and cardiac output.

化学数据

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

储备液配制

以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。