您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SCH900776 S-isomer(MK-8776 S-isomer)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SCH900776 S-isomer(MK-8776 S-isomer)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SCH900776 S-isomer(MK-8776 S-isomer)图片
CAS NO:891494-64-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

SCH900776 S-isomer is the S-isomer of SCH900776 (MK-8776), which is a novel, highly potent and selective Chk1 (cell cycle checkpoint kinase 1) inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. SCH900776 (MK-8776) is an agent with potential radiosensitization and chemosensitization activities. MK-8776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

纯度:≥98%

CAS:891494-64-7