SCH900776 S-isomer is the S-isomer of SCH900776 (MK-8776), which is a novel, highly potent and selective Chk1
(cell cycle checkpoint kinase 1) inhibitor with IC50 of 3 nM in a
cell-free assay. It shows 500-fold selectivity against Chk2. SCH900776
(MK-8776) is an agent with potential radiosensitization and
chemosensitization activities. MK-8776 specifically binds to and
inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent
cell cycle arrest in the S and G2/M phases to undergo DNA repair prior
to entry into mitosis; tumor cells may thus be sensitized to the
DNA-damaging effects of ionizing radiation and alkylating
chemotherapeutic agents.
纯度:≥98%
CAS:891494-64-7