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Acitretin sodium(Ro 10-1670)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:925701-88-8
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议

产品介绍

Acitretin (also known as Etretin, RO 10-1670; Soriatane; Etretin; Neotigason) is a novel, potent, orally bioavailable, second generation retinoid used for psoriasis. Acitretin stimulates ADAM10 promoter activity with an EC50 of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content.

纯度:≥98%

CAS:925701-88-8