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Methylprednisolone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methylprednisolone图片
CAS NO:83-43-2
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
Methylprednisolone (formerly NSC-19987; U-7532; NSC19987) is a synthetic glucocorticoid receptor agonist approved for use in the treatment of arthritis and bronchial inflammation or acute bronchitis. It is also used in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus.
理化性质和储存条件
Molecular Weight (MW)374.47
FormulaC22H30O5
CAS No.83-43-2(Methylprednisolone);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 75 mg/mL (200.3 mM)
Water:<1 mg/mL
Ethanol: 2 mg/mL (5.3 mM)
SMILES
O=C1C=C[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@@](O)(C(CO)=O)CC[C@@]4([H])[C@]3([H])C[C@H](C)C2=C1
SynonymsNSC-19987; U-7532; NSC 19987; U 7532; NSC19987; U7532;
实验参考方法
In Vitro

In vitro activity: Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages.

In VivoMethylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes.
Animal model Rats
Formulation & Dosage 30 mg/kg
ReferencesClin Exp Immunol. 1996 Oct;106(1):91-6; J Neurosci. 2003 Aug 6;23(18):6993-7000.