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Betamethasone(NSC-39470 SCH-4831)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Betamethasone(NSC-39470 SCH-4831)图片
CAS NO:378-44-9
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)392.46
FormulaC22H29FO5
CAS No.378-44-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 79 mg/mL (201.3 mM)
Water: <1 mg/mL
Ethanol: 10 mg/mL (25.5 mM)
SMILESC[C@@]12[C@](C[C@H](C)[C@]2(O)C(CO)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O
SynonymsNSC-39470; SCH-4831; NSC39470; SCH4831; NSC 39470; SCH 4831
实验参考方法
In Vitro

In vitro activity: Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions.

In VivoBetamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10.
Animal modelSheep
Formulation & Dosage
References

J Physiol. 2000 Nov 1;528(Pt 3):619-32; Ann Clin Lab Sci. 2006 Winter;36(1):39-46.