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Genipin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Genipin图片
CAS NO:6902-77-8
包装:10mg, 50mg, 100mg
包装与价格:
包装价格(元)
10mM*1mL in DMSO电议
10mg电议
50mg电议
100mg电议

产品名称
(+)-Genipin
产品介绍

生物活性

Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis. Genipin is a hydrolytic product of geniposide. Genipin has been used in traditional Chinese medicine. Genipin is used in traditional Chinese medicine to relieve the symptoms of type 2 diabetes. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. Genipin has a low acute toxicity, with LD50 i.v. 382 mg/kg in mice. Therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking regents. Genipin is also used for pharmaceutical purposes, such as choleretic action for liver diseases control. Furthermore,genipin can be used as a cross-linking agent for immobilized enzyme, the regulating agent for drug delivery, the raw materials for gardenia blue pigment preparation,as well as the intermediate for alkaloid synthetic etc. Genipin is a naturally occurring material that shows great potential as a use in biomaterials and also as a fingerprint reagent.


化学数据

分子量226.23
分子式C11H14O5
CAS号6902-77-8
纯度99.93%
溶解性(25°C)DMSO 35 mg/mL
储存和运输条件2-8°C, protect from light
常温运输及临时存放

不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

小鼠大鼠豚鼠仓鼠
重量 (kg)0.020.151.80.40.0810
体表面积 (m2)0.0070.0250.150.050.020.5
Km系数36128520
动物 A (mg/kg) = 动物 B (mg/kg) × 动物 B的Km系数
动物 A的Km系数

例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。


储备液配制

以下数据基于产品分子量,对于特殊产品,请参照COA中的储备液配制条件和说明进行操作。

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
1 mM4.4203 mL22.1014 mL44.2028 mL
5 mM0.8841 mL4.4203 mL8.8406 mL
10 mM0.442 mL2.2101 mL4.4203 mL