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Tretazicar(CB 1954)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tretazicar(CB 1954)图片
CAS NO:21919-05-1
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍

Tretazicar (CB-1954; CB1954), a dinitrobenzamide analog and prodrug, is a potent and highly selective DNA alkylating agent that generates highly cytotoxic interstrand crosslinks in DNA. It is converted into a potent cytotoxic bifunctional DNA-alkylating agent in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP). CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino analogues, whereupon the non-enzymatic reaction of the 4-hydroxylamino analogue with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.

纯度:≥98%

CAS:21919-05-1