Formestane(CGP-32349)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	566-48-3
规格:	≥98%

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议
1g	电议
2g	电议
5g	电议

产品介绍

Formestane (formerly also known as CGP-32349, NSC 282175) is a second generation, selective, orally bioactive and synthetic steroidal aromatase inhibitor with an IC50 of 80 nM. Formestane is a substance with anticancer activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.

理化性质和储存条件

Molecular Weight (MW)	302.41
Formula	C19H26O3
CAS No.	566-48-3
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 61 mg/mL (201.7 mM)
	Water: <1 mg/mL
	Ethanol:<1 mg/mL
Other info	Chemical Name: (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione InChi Key: OSVMTWJCGUFAOD-KZQROQTASA-N InChi Code: InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1 SMILES Code: O=C(C(O)=C1CC[C@@]2([H])[C@]3([H])CC4)CC[C@]1(C)[C@@]2([H])CC[C@]3(C)C4=O
Synonyms	CGP-32349, NSC282175; NSC-282175; NSC 282175; CGP32349; CGP 32349; CGP-32349; 4OHA; 4OHAD; Formestane; Lentaron.