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WEHI-345
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WEHI-345图片
CAS NO:1354825-58-3
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

WEHI-345 (WEHI345) is a novel, potent and selective RIPK2 inhibitor with therapeutic potential to treat NOD-driven inflammatory diseases. It inhibits RIPK2 with an IC50 of 0.13 μM and shows NOD signalling events yet prevents inflammatory cytokine production. Intracellular nucleotide binding and oligomerization domain (NOD) receptors recognize antigens including bacterial peptidoglycans and initiate immune responses by triggering the production of pro-inflammatory cytokines through activating NF-κB and MAP kinases. Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. Despite only delaying NF-κB activation on NOD stimulation, WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.

纯度:≥98%

CAS:1354825-58-3