VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H4 receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH4 receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction. References: Nijmeijer S, Engelhardt H, Schultes S, van de Stolpe AC, Lusink V, de Graaf C, Wijtmans M, Haaksma EE, de Esch IJ, Stachurski K, Vischer HF, Leurs R. Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H4 receptor. Br J Pharmacol. 2013 Sep;170(1):89-100. doi: 10.1111/bph.12113. PubMed PMID: 23347159; PubMed Central PMCID: PMC3764852.

纯度：≥98%

CAS：1605304-31-1