AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release. This apoptotic response was significantly higher for AK301 than for other mitotic inhibitors tested (colchicine, vincristine, and BI 2536). References: Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS One. 2016 Apr 20;11(4):e0153818. doi: 10.1371/journal.pone.0153818. PubMed PMID: 27097159; PubMed Central PMCID: PMC4838221.

纯度：≥98%

CAS：314022-97-4