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AKI-001
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AKI-001图片
CAS NO:925218-37-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
50mg电议
500mg电议

产品介绍

AKI-001 is a novel, potent and orally bioactive Aurora kinase inhibitor based on a pentacyclic scaffold, exhibiting low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An orally bioavailable dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.

纯度:≥98%

CAS:925218-37-7