CAS NO: | 925218-37-7 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
50mg | 电议 |
500mg | 电议 |
AKI-001 is a novel, potent and orally bioactive Aurora kinase inhibitor based on a pentacyclic scaffold, exhibiting low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An orally bioavailable dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.
纯度:≥98%
CAS:925218-37-7