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Isovaleramide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isovaleramide图片
CAS NO:541-46-8
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)101.15
FormulaC5H11NO
CAS No.541-46-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 20 mg/mL (197.7 mM)
Water: <1 mg/mL
Ethanol: 20 mg/mL (197.7 mM)
Other info

Chemical Name: 3-Methylbutanamide

InChi Key: SANOUVWGPVYVAV-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H11NO/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H2,6,7)

SMILES Code: CC(C)CC(N)=O

Synonyms

3-Methylbutanamide; NPS-1776; Isovaleramide; NPS 1776; NPS1776;

实验参考方法
In Vitro

In vitro activity: Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. It is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 μM) exhibits a 42% of inhibition of the binding of 3H-FNZ to its sites in the in vitro assay. Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3.

In VivoIsovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits.
Animal modelMice
Formulation & Dosage100 mg/Kg, p.o
References

Biomedica. 2010 Apr-Jun;30(2):245-50; Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.