| CAS NO: | 552-41-0 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 166.17 |
|---|---|
| Formula | C9H10O3 |
| CAS No. | 552-41-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 33 mg/mL (198.6 mM) |
| Water: <1 mg/mL | |
| Ethanol: 33 mg/mL (198.6 mM) | |
| Other info | Chemical Name: 1-(2-Hydroxy-4-methoxyphenyl)ethanone InChi Key: UILPJVPSNHJFIK-UHFFFAOYSA-N InChi Code: InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 SMILES Code: CC(C1=CC=C(OC)C=C1O)=O |
| Synonyms | NSC-401442; NSC401442; Peonol; NSC 401442; |
| In Vitro | In vitro activity: Paeonol (Peonol) is a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum. It has demonstrated significant MAOI activity. MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively. Paeonol shows antimutagenic, anti-inflammatory and analgesic effects. Paeonol also inhibits anaphylactic reaction by regulating histamine and TNF-α. |
|---|---|
| In Vivo | The 200 mg/kg Paeonol+I/R group [AN/V (%): 7.6±2.2, p<0.01] and 100 mg/kg Paeonol+I/R group [AN/V (%): 9.4±2.8, p<0.05] both show lesser extents of no-reflow area in the ventricles compared with the I/R group [AN/V (%): 18.2±2.9]. In particular, the 200 mg/kg Paeonol + I/R group experienced markedly alleviated no-reflow in the whole heart [AN/WH (%): 4.6±1, p<0.05] compared with the I/R group [AN/WH (%): 10.0±1.9] |
| Animal model | Male Wistar rats |
| Formulation & Dosage | 100, 200 mg/kg; oral |
| References | J Ethnopharmacol. 2004 Apr;91(2-3):351-5; Int Immunopharmacol. 2004 Feb;4(2):279-87. |
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