BMS453 (BMS-453) is a novel and potent agonist of retinoic acid receptor β (RARβ) agonist with anticancer activity. Also acting as a RARα and RARγ antagonist. BMS453 could inhibit normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest. Retinoic acid receptors (RARα, RARβ, RARγ) belong to steroid nuclear receptor superfamily and the expressions of retinoid receptor RARα and RARβ are correlated with the antiproliferative effects of retinoids.

纯度：≥98%

CAS：166977-43-1