PIP-199 is a novel, potent and selective inhibitor of protein-protein interaction between the RMI (RecQ-mediated genome instability protein) core complex and FANCM (a peptide referred to as MM2). Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies. Proper execution of the FA pathway requires interaction between the FA complementation group M protein (FANCM) and the RecQ-mediated genome instability protein (RMI) complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents. Inhibitors that block FANCM/RMI complex formation could be useful therapeutics for re-sensitizing tumors that have acquired chemotherapeutic resistance.

纯度：≥98%

CAS：622795-76-0