| CAS NO: | 70458-96-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 50g | 电议 |
| 100g | 电议 |
| Molecular Weight (MW) | 319.33 |
|---|---|
| Formula | C16H18FN3O3 |
| CAS No. | 70458-96-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 3 mg/mL (9.4 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid InChi Key: OGJPXUAPXNRGGI-UHFFFAOYSA-N InChi Code: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) SMILES Code: O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O |
| Synonyms | MK-0366; Norfloxacin, AM-715, MK 0366; MK0366; AM715, MK-366, AM 715, MK366, MK 366, Noroxin, Chibroxin |
| In Vitro | In vitro activity: Norfloxacin (MK-0366) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Clin Infect Dis. 2007 Apr 1;44(7):977-80. Epub 2007 Feb 14. |
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