Aminaphthone, formerly known as Capilarema, is a drug used for the treatment of capillary disorders. Aminaftone inhibits ET-1 production in cell cultures by interfering with transcription of the PPET-1 gene. Aminaftone reduced plasma concentration of ET-1 and seemed to reduce right heart hypertrophy and the wall thickness of the pulmonary arteries at the highest dose. Aminaftone may represent a novel treatment strategy of pulmonary hypertension. References: Martinez-Zapata MJ, Vernooij RW, Uriona Tuma SM, Stein AT, Moreno RM, Vargas E, Capellà D, Bonfill Cosp X. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016 Apr 6;4:CD003229. doi: 10.1002/14651858.CD003229.pub3. Review. PubMed PMID: 27048768.

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CAS：14748-94-8