您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Nifedipine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Nifedipine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nifedipine图片
CAS NO:21829-25-4
包装:100mg, 500mg
包装与价格:
包装价格(元)
Free Sample (0.5-1 mg)电议
100mg电议
500mg电议
1g电议

产品名称
BAY-a-1040
产品介绍

生物活性

Nifedipine (BAY-a-1040), a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal’s angina) and antihypertensive, although a large number of other uses have recently been found for this agent, such as Raynaud’s phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.


化学数据

分子量346.33
分子式C17H18N2O6
CAS号21829-25-4
纯度>99%
溶解性(25°C)DMSO 59 mg/mL
储存和运输条件-20°C, protect from light, sealed
常温运输及临时存放

实验操作 来自于公开的文献,仅供相同实验参考(如实验材料、目的不同,请参考其他文献)

细胞实验
细胞系TM4 cells
方法Effects of extracellular calcium ion and calcium channel blocker on Sertoli cell phagocytosis. TM4 cells were cultured for two hours and then treated with or without 10 μM nifedipine for additional 20 hours. Fluorescent carboxyl microspheres were then added to wells for further two hours as usual. Culture medium of some untreated wells was replaced by one mM EGTA containing culture medium (Ca; 0.1 mM) just before addition of microspheres. Cells were then evaluated for phagocytosis by flow cytometric analysis. Calcium concentration of untreated or one mM EGTA growth medium was one mM or 0.1 mM, respectively.
浓度10 μM
处理时间20 hours

动物实验
动物模型
配制
剂量
给药处理

不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

小鼠大鼠豚鼠仓鼠
重量 (kg)0.020.151.80.40.0810
体表面积 (m2)0.0070.0250.150.050.020.5
Km系数36128520
动物 A (mg/kg) = 动物 B (mg/kg) × 动物 B的Km系数
动物 A的Km系数

例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。


储备液配制

以下数据基于产品分子量,对于特殊产品,请参照COA中的储备液配制条件和说明进行操作。

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
1 mM2.8874 mL14.4371 mL28.8742 mL
5 mM0.5775 mL2.8874 mL5.7748 mL
10 mM0.2887 mL1.4437 mL2.8874 mL