| CAS NO: | 10212-25-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 261.66 |
|---|---|
| Formula | C9H12ClN3O4 |
| CAS No. | 10212-25-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 52 mg/mL (198.7 mM) |
| Water: 44 mg/mL (168.2 mM) | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride InChi Key: KZOWNALBTMILAP-JBMRGDGGSA-N InChi Code: InChI=1S/C9H11N3O4.ClH/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8;/h1-2,4,6-8,10,13-14H,3H2;1H/t4-,6-,7+,8-;/m1./s1 SMILES Code: OC[C@@H](O1)[C@@H](O)[C@H](OC2=N3)[C@@H]1N2C=CC3=N.Cl |
| Synonyms | Ancitabine Cyclo-CMP hydrochloride; NSC 145668; NSC-145668; Cyclo-C; NSC 145668 HCl; Ancitabine HCl; Cyclocytidine HCl; NSC145668; |
| In Vitro | In vitro activity: Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. |
|---|---|
| In Vivo | Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. Cyclocytidine provides treatment for leukemia. |
| Animal model | BDF1 mice inoculated L1210 cells |
| Formulation & Dosage | Dissolved in Vehicle 122; 20 or 100 mg/kg/day; i.p. or s.c. administration |
| References | J Pharm Sci. 1984 Jul;73(7):896-902; Biochem Pharmacol. 1972 Feb 15;21(4):465-75. |
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