PF-9404C is the S-S diesteroisomer of a novel blocker of beta adrenergic receptors with vasodilatory properties. In rat aorta smooth muscle cells, PF9404C increased the formation of cyclic GMP from 3 pmol mg–1 protein in basal conditions, to 53 pmol mg–1 protein in 10 μM. References: Villarroya M, López MG, de Pascual R, García AG. Preclinical profile of PF9404C, a nitric oxide donor with beta receptor blocking properties. Cardiovasc Drug Rev. 2005 Summer;23(2):149-60. Review. PubMed PMID: 16007231.
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CAS:780825-97-0