您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > YK-4-279
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
YK-4-279
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YK-4-279图片
CAS NO:1037184-44-3
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)366.20
FormulaC17H13Cl2NO4
CAS No.1037184-44-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 73 mg/mL (199.3 mM)
Water: <1 mg/mL
Ethanol: 51 mg/mL (139.3 mM)
Other info

Chemical Name: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one

InChi Key: HLXSCTYHLQHQDJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22)

SMILES Code: O=C1NC2=C(C(Cl)=CC=C2Cl)C1(O)CC(C3=CC=C(OC)C=C3)=O

Synonyms

YK-4-279; YK-4279; YK4279; YK4-279; YK 4-279; YK 4279.

实验参考方法
In Vitro

In vitro activity: YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion

In VivoIn vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors.
Animal modelNude mice bearing prostate cancer PC3, TC71 or CHP-100 xenografts
Formulation & DosageDissolved in DMSO; 1.5 mg/dose; i.p. injection
References

Nat Med. 2009 Jul;15(7):750-6; PLoS One. 2014 Dec 5;9(12):e114260.