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Xylometazoline HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Xylometazoline HCl图片
CAS NO:1218-35-5
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)280.84
FormulaC16H24N2.HCl
CAS No.1218-35-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 27 mg/mL (96.1 mM)
Water: 56 mg/mL (199.4 mM)
Ethanol: 56 mg/mL (199.4 mM)
Other infoChemical Name: 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole hydrochloride

InChi Key: YGWFCQYETHJKNX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H

SMILES Code: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1.[H]Cl

SynonymsTrade name: Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal.
实验参考方法
In Vitro

In vitro activity: Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.

In Vivo
Animal model
Formulation & Dosage
References

Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.