Xevinapant HCl (formerly Debio-1143 HCl; AT406; SM406, ARRY334543 HCl) is a potentially first-in-class and oral antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) proteins, also a peptidomimetic of SMAC (second mitochondrial-derived activator of caspases)/DIABLO with potential antitumor activity. It acts by binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Kis of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

纯度：≥98%

CAS：1071992-57-8