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Penfluridol(R-16341)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Penfluridol(R-16341)图片
CAS NO:26864-56-2
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)523.97
FormulaC28H27ClF5NO
CAS No.26864-56-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (190.9 mM)
Water: <1 mg/mL
Ethanol: 100 mg/mL (190.9 mM)
Other info

Chemical Name: 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

InChi Key: MDLAAYDRRZXJIF-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

SMILES Code: OC1(C2=CC=C(Cl)C(C(F)(F)F)=C2)CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC1

SynonymsTLP-607; McN-JR-16341; R-16341; McNJR16341; R16341; TLP607; TLP 607; McN JR 16341; R 16341; Acemap; Semap
实验参考方法
In Vitro

In vitro activity: Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. Penfluridol selectively inhibits the binding of [3H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. Penfluridol (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation.

In Vivo
Animal model
Formulation & Dosage
References

Science. 1976 Apr 30;192(4238):481-3; Proc Natl Acad Sci U S A. 1985 Feb;82(4):1237-41.