PD 130883 is a potent lipophilic quinazoline antifolate. References: Seither RL, Trent DF, Mikulecky DC, Rape TJ, Goldman ID. Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition. J Biol Chem. 1991 Mar 5;266(7):4112-8. PubMed PMID: 1825652.

纯度：≥98%

CAS：123685-36-9