Fumagillin(Amebacilin NSC9168)

Molecular Weight (MW)	458.54
Formula	C26H34O7
CAS No.	23110-15-8
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 92 mg/mL (200.6 mM)
Water: <1 mg/mL
Ethanol: 32 mg/mL (69.8 mM)
Other info	Chemical Name: (2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid InChi Key: NGGMYCMLYOUNGM-IJIYPQOHSA-N InChi Code: InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25+,26+/m1/s1 SMILES Code: O=C(O)/C=C/C=C/C=C/C=C/C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)OC2C/C=C(C)\C)[C@]31CO3)=O
Synonyms	NSC9168; NSC 9168; NSC-9168; Fumidil B; trade names: Fumagilina; Fugillin; Fumidil.

Molecular Weight (MW)

458.54

Formula

C26H34O7

CAS No.

23110-15-8

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 92 mg/mL (200.6 mM)

Water: <1 mg/mL

Ethanol: 32 mg/mL (69.8 mM)

Other info

Chemical Name: (2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid
InChi Key: NGGMYCMLYOUNGM-IJIYPQOHSA-N
InChi Code: InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25+,26+/m1/s1
SMILES Code: O=C(O)/C=C/C=C/C=C/C=C/C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)OC2C/C=C(C)\C)[C@]31CO3)=O

Synonyms

NSC9168; NSC 9168; NSC-9168; Fumidil B; trade names: Fumagilina; Fugillin; Fumidil.

In Vitro	In vitro activity: Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases.
In Vivo	In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis.
Animal model	Rats
Formulation & Dosage	30 mg/kg, i.p.
References	Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103; World J Gastroenterol. 2005 Feb 14;11(6):771-7.

In Vitro

In vitro activity: Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases.

In Vivo

In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis.

Animal model

Rats

Formulation & Dosage

30 mg/kg, i.p.

References

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103; World J Gastroenterol. 2005 Feb 14;11(6):771-7.

CAS NO:	23110-15-8
规格:	≥98%

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议