BMS-193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that exhibits > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. It reduces food intake and body weight via central Y1 inhibition and is brain penetrant. References: Hussain S, Richardson E, Ma Y, Holton C, De Backer I, Buckley N, Dhillo W, Bewick G, Zhang S, Carling D, Bloom S, Gardiner J. Glucokinase activity in the arcuate nucleus regulates glucose intake. J Clin Invest. 2015 Jan;125(1):337-49. doi: 10.1172/JCI77172. Epub 2014 Dec 8. PubMed PMID: 25485685; PubMed Central PMCID: PMC4382228.

纯度：≥98%

CAS：186185-03-5