Ono-3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo and may be of therapeutic use in preventing cerebral vasospasm. Recent studies suggest that Ono-378 could play an important role in the pathogenesis of thrombosis and that ONO-3708 may have therapeutic advantages in preventing thrombosis. References: Tanaka Y, Nakayama K, Shigenobu K. Inhibitory actions of ONO-3708 on the stretch-induced contraction potentiated by hemolysate/oxyhemoglobin studied in dog cerebral artery. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):303-11. PubMed PMID: 9485524. 2: Li BY, Qiao GF, Sun JP, Gao YR, Li WH. Inhibitory effects of ONO-3708 and S-145 on shape change and aggregation of rabbit platelets induced by STA2. Zhongguo Yao Li Xue Bao. 1996 Jul;17(4):345-8. PubMed PMID: 9812720. 3: Haba Y, Kuroda T. Thromboxane A2 receptor antagonist (ONO 3708) protects from liver damage induced by cholestasis and ischemia-reperfusion. Eur Surg Res. 1995;27(2):100-10. PubMed PMID: 7781641. 4: Hanazaki K, Kuroda T, Haba Y, Shiohara E, Kajikawa S, Iida F. Protective effect of the thromboxane A2 receptor antagonist ONO 3708 on ischemia-reperfusion injury in the dog liver. Surgery. 1994 Nov;116(5):896-903. PubMed PMID: 7940195. 5: Kuroda T, Shiohara E, Haba Y, Hanazaki K. The effect of a thromboxane A2 receptor antagonist (ONO 3708) on ischemia-reperfusion injury of the dog pancreas. Transplantation. 1994 Jan;57(2):187-94. PubMed PMID: 7508645. 6: Nagai H, Kumimoto M, Yoshitake K, Iwama T, Arimura A, Koda A. The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs. Prostaglandins Leukot Essent Fatty Acids. 1992 Mar;45(3):233-8. PubMed PMID: 1534171. 7: Hanazaki K. [Assessment for protective effects of CoQ10, PGE1 and TXA2 receptor antagonist (ONO-3708) on warm ischemic liver]. Nihon Geka Gakkai Zasshi. 1992 Mar;93(3):274-87. Japanese. PubMed PMID: 1387460. 8: Nagai H, Tsuji F, Inagaki N, Kitagaki K, Fukutomi O, Koda A, Daikoku M. The effect of ONO-3708, a novel TxA2 receptor antagonist, on U-46619-induced contraction of guinea pig and human tracheal strips in vitro and on bronchoconstriction in guinea pigs in vivo. Prostaglandins. 1991 Apr;41(4):375-82. PubMed PMID: 1831278. 9: Shimazawa T, Nagai H, Koda A, Kasahara M. The effects of thromboxane A2 inhibitors (OKY-046 and ONO-3708) and leukotriene inhibitors (AA-861 and LY-171883) on CCl4-induced chronic liver injury in mice. Prostaglandins Leukot Essent Fatty Acids. 1990 May;40(1):67-71. PubMed PMID: 2119043. 10: Nagai H, Aoki M, Shimazawa T, Yakuo I, Koda A, Kasahara M. Effect of OKY-046 and ONO-3708 on liver injury in mice. Jpn J Pharmacol. 1989 Oct;51(2):191-7. PubMed PMID: 2512404. 1 Kondo K, Seo R, Omawari N, Imawaka H, Wakitani K, Kira H, Okegawa T, Kawasaki A. Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on blood vessels. Eur J Pharmacol. 1989 Sep 13;168(2):193-200. PubMed PMID: 2606148. 12: Sasao J, Taneyama C, Kimura M, Kiyono S. [The effects of ONO 3708, a new thromboxane receptor antagonist, on cardiovascular response during the early phases of endotoxin shock in anesthetized dogs]. Masui. 1989 Sep;38(9):1188-94. Japanese. PubMed PMID: 2810716. 13: Taneyama C, Sasao J, Senna S, Kimura M, Kiyono S, Goto H, Arakawa K. Protective effects of ONO 3708, a new thromboxane A2 receptor antagonist, during experimental endotoxin shock. Circ Shock. 1989 May;28(1):69-77. PubMed PMID: 2525079. 14: Kondo K, Seo R, Naka M, Kitagawa T, Wakitani K, Sakata M, Kira H, Okegawa T, Kawasaki A. Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on platelet aggregation and thrombosis. Eur J Pharmacol. 1989 Apr 25;163(2-3):253-61. PubMed PMID: 2721574. 15: Torii T, Toki Y, Hieda N, Ito Y, Okumura K, Hashimoto H, Ito T, Ogawa K, Satake T. Effects of a new thromboxane A2-antagonist (ONO-3708) and a new leukotriene-antagonist (ONO-1078) on thromboxane A2 analogue-, leukotriene C4-, and D4-induced regional myocardial blood flow reduction. Heart Vessels. 1988;4(2):104-11. PubMed PMID: 3253270. 16: Suga H, Hamanaka N, Kondo K, Miyake H, Ohuchida S, Arai Y, Kawasaki A. ONO-3708: an effective thromboxane A2 antagonist possessing 3-acylaminopinane skeleton. Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:799-802. PubMed PMID: 2960194. 17: Kondo K, Seo R, Kitagawa T, Omawari N, Kira H, Okegawa T, Kawasaki A. Preventive effect of ONO-3708 on thrombosis and vasospasms in vitro and in vivo. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:423-6. PubMed PMID: 2959089. 18: Ito T, Ito Y, Torii T, Hieda N, Toki Y, Miyazaki Y, Hashimoto H, Ogawa K, Satake T. Protective effects of selective inhibitor of thromboxane synthetase (OKY-046) and thromboxane antagonist (ONO-3708) on ischemia-induced mitochondrial dysfunction in canine heart. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:392-6. PubMed PMID: 2959085. 19: Fujioka M, Nagao T, Kuriyama H. Actions of the novel thromboxane A2 antagonists, ONO-1270 and ONO-3708, on smooth muscle cells of the guinea-pig basilar artery. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):468-74. PubMed PMID: 3821937. 20: Kattelman EJ, Venton DL, Le Breton GC. Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548). Thromb Res. 1986 Feb 15;41(4):471-81. PubMed PMID: 3008368.

纯度：≥98%

CAS：102191-05-9