Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation. References: Sun H, He X, Liu C, Li L, Zhou R, Jin T, Yue S, Feng D, Gong J, Sun J, Ji J, Xiang L. Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models. ACS Chem Neurosci. 2017 Jan 18;8(1):155-164. doi: 10.1021/acschemneuro.6b00291. Epub 2016 Oct 25. PubMed PMID: 27731637.

纯度：≥98%

CAS：1021950-79-7