AS101, formerly known as Ossirene, is a synthetic non-toxic tellurium analogue, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. Ammonium trichlorotellurate may inhibit the inflammatory cytokine interleukin-10 (IL-10) and may induce hematopoietic cells to express interleukin-2 (IL-2), IL-2 receptors, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, tumor necrosis factor (TNF) and interferons (INFs). This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced myelosuppression. In addition, this agent exhibits hair growth-promoting activity by inducing anagen production and inhibiting catagen production, resulting in the promotion of follicular keratinocyte proliferation and interference with follicular keratinocyte terminal differentiation, respectively. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. References: Indenbaum V, Bin H, Makarovsky D, Weil M, Shulman LM, Albeck M, Sredni B, Mendelson E. In vitro and in vivo activity of AS101 against West Nile virus (WNV). Virus Res. 2012 Mar 14. [Epub ahead of print] PubMed PMID: 22445690.

纯度：≥98%

CAS：106566-58-9