Flucloxacillin
(Floxacillin, Floxapen) is a potent and narrow-spectrum beta-lactam antibiotic with activity against gram-positive and gram-negative bacteria. It is used to treat infections caused by susceptible Gram-positive bacteria.
Unlike other penicillins, flucloxacillin is beta-lactamase stable and thus has activity against beta-lactamase-producing organisms such as Staphylococcus aureus as it is. However, it is ineffective against methicillin-resistant Staphylococcus aureus (MRSA). It is very similar to dicloxacillin and they are considered to be interchangeable.理化性质和储存条件
Molecular Formula: C19H17ClFN3O5S;
Molecular Weight: 453.87
In Vivo | The serum elimination half-life of flucloxacillin is 1.31-1.39 hours, and six hours after administration of a single 250 mg dose the serum concentration of flucloxacillin is 0.46 micrograms/mL[1]. Oral flucloxacillin does not affect sweat electrolytes and is not a contraindication to sweat testing[2]. Flucloxacillin has been reported to be metabolized in man to the penicilloic acid, the antibacterially active 5'-hydroxymethyl derivative and the penicilloic acid of the 5'-hydroxymethyl derivative. The metabolism of flucloxacillin in the rat is similar[3]. |
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Animal Protocol | Rats: On the day of the experiment the animal is given an intravenous bolus injection of 200 mg/kg as pure free acid sodium flucloxacillin (dose volume: 1 mL sterile water per kg) and then return to the metabolism cage. Urine is collected directly into individual CO2 cooled containers for a period of 24 h before dosing and then at frequent intervals after dosing[3]. |
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