NS9283 is a positive allosteric modulator of α4β2 receptor. NS9283 increases the potency of Ach-evoked currents ~60 fold without effecting the maximum efficacy (HEK293-hα4β2 cells). It reduces the rate of recovery from desensitization and slows the rate of deactivation. References: Maurer JJ, Sandager-Nielsen K, Schmidt HD. Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283. Psychopharmacology (Berl). 2017 Feb;234(3):475-484. doi: 10.1007/s00213-016-4475-7. Epub 2016 Nov 14. PubMed PMID: 27844094.

纯度：≥98%

CAS：913830-15-6