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Atorvastatin hemicalcium trihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atorvastatin hemicalcium trihydrate图片
CAS NO:344920-08-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
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25mg电议
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100mg电议

产品介绍
理化性质和储存条件

Molecular Formula: C33H35FN2O5.1/2Ca.3H2O;

Molecular Weight: 632.73


    In VitroAtorvastatin hemicalcium trihydrate treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4].
    In VivoAtorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE–/– mice) hemicalcium trihydrate treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5]. Animal Model: Forty 8-week-old ApoE–/– mice induced with angiotensin II (Ang II)[5] Dosage: 20 mg/kg, 30 mg/kg Administration: Oral gavage; once a day; for 28 days Result: Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE–/– mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.