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Droxidopa(L-DOPS SM5688))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Droxidopa(L-DOPS SM5688))图片
CAS NO:23651-95-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)213.19
FormulaC9H11NO5
CAS No.23651-95-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: (2R,3S)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

InChi Key: QXWYKJLNLSIPIN-SFYZADRCSA-N

InChi Code: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m1/s1

SMILES Code: O=C(O)[C@H](N)[C@H](C1=CC=C(O)C(O)=C1)O

SynonymsL-DOPS; SM5688; Droxidopa; trade name: Northera; LDOPS; SM 5688; SM-5688; L-threodihydroxyphenylserine
实验参考方法
In Vitro

In vitro activity: Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline. Droxidopa is well tolerated. Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure. Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain.

In VivoThe acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa(L-DOPS) is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. It has no pressor effects in this form. It can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline
Animal modelRats
Formulation & DosageN/A
References

Clin Auton Res. 2008 Mar;18 Suppl 1:25-9; Clin Auton Res. 2001 Aug;11(4):235-42.