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Medetomidine HCl(MPV-785)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Medetomidine HCl(MPV-785)图片
CAS NO:86347-15-1
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)236.74
FormulaC13H16N2.HCl
CAS No.86347-15-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 12 mg/mL (50.7 mM)
Water: 47 mg/mL (198.5 mM)
Ethanol: 47 mg/mL (198.5 mM)
Solubility (In vivo)Saline: 30 mg/mL
SynonymsMPV-785; Medetomidine HCl; Medetomidine hydrochloride; MPV 785; MPV785; Precedex. Domitor. Selektope.
实验参考方法
In Vitro

In vitro activity: Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors.

In VivoIn anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover.
Animal modelRat
Formulation & DosageDissolved in saline; 1-100 μg/kg; i.v. injection
References

Eur J Pharmacol. 1988 May 20;150(1-2):9-14; J Auton Pharmacol. 1986 Dec;6(4):275-84.