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Dexmedetomidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dexmedetomidine图片
CAS NO:113775-47-6
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)200.28
FormulaC13H16N2
CAS No.113775-47-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 40 mg/mL (199.7 mM)
Water: 40 mg/mL (199.7 mM)
Ethanol: 40 mg/mL (199.7 mM)
Other info

Chemical Name: 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

InChi Key: CUHVIMMYOGQXCV-NSHDSACASA-N

InChi Code: InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1

SMILES Code: CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C

SynonymsDexmedetomidine HCl; Dexmedetomidine Hydrochloride; Precedex;
实验参考方法
In Vitro

In vitro activity: Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

In Vivo
Animal model
Formulation & Dosage
References

Eur J Pharmacol. 1988 May 20;150(1-2):9-14; Anesthesiology. 1997 Feb;86(2):331-45.