Propranolol HCl(AY64043,ICI45520,NCS91523)

Molecular Weight (MW)	295.8
Formula	C16H21NO2.HCl
CAS No.	318-98-9
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 59 mg/mL (199.5 mM)
Water: 6 mg/mL (20.3 mM)
Ethanol: <1 mg/mL
Other info	Chemical Name: 1-Naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride InChi Key: ZMRUPTIKESYGQW-UHFFFAOYSA-N InChi Code: InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H SMILES Code: OC(CNC(C)C)COC1=C2C=CC=CC2=CC=C1.[H]Cl
Synonyms	AY-64043, ICI-45520, NCS-91523; AY 64043, ICI 45520, NCS 91523; AY64043, ICI45520, NCS91523;

Molecular Weight (MW)

295.8

Formula

C16H21NO2.HCl

CAS No.

318-98-9

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 59 mg/mL (199.5 mM)

Water: 6 mg/mL (20.3 mM)

Ethanol: <1 mg/mL

Other info

Chemical Name: 1-Naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride

InChi Key: ZMRUPTIKESYGQW-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

SMILES Code: OC(CNC(C)C)COC1=C2C=CC=CC2=CC=C1.[H]Cl

Synonyms

AY-64043, ICI-45520, NCS-91523; AY 64043, ICI 45520, NCS 91523; AY64043, ICI45520, NCS91523;

In Vitro	In vitro activity: Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
In Vivo	Propranolol hydrochloride (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant
Animal model	Mouse model of IH (infantile hemangiomas) with HemSC cells
Formulation & Dosage	40 mg/kg; oral
References	[1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1 [2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [4]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55.

In Vitro

In vitro activity: Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

In Vivo

Propranolol hydrochloride (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant

Animal model

Mouse model of IH (infantile hemangiomas) with HemSC cells

Formulation & Dosage

40 mg/kg; oral

References

[1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1

[2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.

[3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.

[4]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55.

CAS NO:	318-98-9
规格:	≥98%

包装	价格(元)
500mg	电议
1g	电议
2g	电议
5g	电议
10g	电议
25g	电议
50g	电议