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Metoprolol tartrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metoprolol tartrate图片
CAS NO:56392-17-7
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)684.81
Formula2C15H25NO3.C4H6O6
CAS No.56392-17-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (146.0 mM)
Water: 100 mg/mL (146.0 mM)
Ethanol: 31 mg/mL (45.2 mM)
Solubility (In vivo)

Chemical Name: (R)-1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol hemi((2R)-2,3-dihydroxysuccinate)

InChi Key: YGULWPYYGQCFMP-RBXXDJRDSA-N

InChi Code: InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t2*14-;1-,2?/m111/s1

SMILES Code: O[C@H](CNC(C)C)COC1=CC=C(CCOC)C=C1.O[C@H](CNC(C)C)COC2=CC=C(CCOC)C=C2.O=C(O)[C@H](O)C(O)C(O)=O

SynonymsCGP 2175E; Lanoc; Lopressor; CGP2175E; CGP-2175E; Metomerck; Metop; Selopral; Ritmolol; Metoprolol Tartrate
实验参考方法
In Vitro

In vitro activity: Metoprolol, attenuates cardiomyocyte apoptosis in left ventricular (LV) myocardium of dogs with heart failure (HF). Metoprolol induces the expression of Bcl-2 independent of heart failure (HF) and that this independently confers protection.

In VivoMetoprolol partly reverses the depressed left ventricular (LV) systolic pressure, positive and negative rates of changes in pressure development, ejection fraction, fractional shortening and cardiac output, as well as increased LV end-diastolic pressure in 20 weeks myocardial infarction (MI) rats. Metoprolol partially reverses the elevated levels of plasma norepinephrine and dopamine without affecting the elevated levels of epinephrine. Metoprolol treatment attenuates the development of cardiac dysfunction in streptozotocin (STZ)-diabetic rats. Metoprolol leads to reduced rates of palmitate oxidation, stimulation of glucose oxidation, and increases tissue ATP levels. Metoprolol leads to decreased maximum activity and decreased sensitivity of carnitine palmitoyltransferase I to malonyl-CoA. Metoprolol also increases sarco(endo) plasmic reticulum Ca(2+)-ATPase expression and prevents the reexpression of atrial natriuretic peptide in diabetic hearts of in streptozotocin (STZ)-diabetic rats. Metoprolol, attenuates the increase in collagen content in noninfarcted regions and prevents the increase in right ventricular weight/body weight, and its effect is similar to captopril in rat model with myocardial infarction (MI). Metoprolol treatment tends to increase right ventricular weight and heart weight.
Animal modelRats
Formulation & Dosage
References

J Am Coll Cardiol. 2000 Nov 1;36(5):1698-705; J Cell Physiol. 2013 Oct;228(10):2063-70.