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Esmolol HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esmolol HCl图片
CAS NO:81161-17-3
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)331.83
FormulaC16H25NO4.HCl
CAS No.81161-17-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 66 mg/mL (198.9 mM)
Water: 66 mg/mL (198.9 mM)
Ethanol: 66 mg/mL (198.9 mM)
Other info

Chemical Name: methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate;hydrochloride

InChi Key: GEKNCWBANDDJJL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H

SMILES Code: CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O.Cl

SynonymsASL-8052; Esmolol Hydrochloride; Esmolol HCL; Brevibloc; ASL-8052; Asl 8052; ASL 8052; ASL8052; ASL 8052; Brevibloc; esmolol; esmolol hydrochloride
实验参考方法
In Vitro

In vitro activity: Esmolol contains one asymmetric centre and exists as an enantiomeric pair, the (-)-enantiomer is active and the (+)-enantiomer is inactive, which is analogous to other P-blockers that have an oxypropranolamine nucleus. Esmolol has a rapid onset and offset of activity, the primary site of activity of Esmolol is on sinus node and atrioventricular (AV) nodal conduction systems.

In VivoEsmolol (20 mg/kg) infusion in sepsis improves oxygen utilization of myocardium and preserves myocardial function in septic rats. Esmolol (5 mg/kg, i.v.) produces a dose-dependent decrease in heart rate (HR) in rabbits, with the maximum percent reductions of 13%. Esmolol (5 mg/kg, i.v.) produces a dose-dependent decrease in mean arterial pressure (MAP) in rabbits, with the maximum percent reductions of 38.2%. Esmolol (300 mg/kg) significantly decreases the heart rate, rate-pressure product, left ventricular contraction, cardiac output, and relative refractory period of the right ventricle, suppresses the AV nodal conduction, and increases the effective refractory period of the right ventricle and the preload of the left ventricle in canine. Esmolol (300 mg/kg) significantly reduces the isoproterenol-induced increase in heart rate and ventricular contraction in canine.
Animal modelRabbits
Formulation & Dosage5 mg/kg, i.v.
References

Clin Pharmacokinet. 1995 Mar;28(3):190-202; Crit Care Med. 2005 Oct;33(10):2294-301.