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Metoclopramide HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metoclopramide HCl图片
CAS NO:7232-21-5
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)336.26
FormulaC14H23Cl2N3O2
CAS No.7232-21-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 67 mg/mL (199.3 mM)
Water: N/A
Ethanol: 67 mg/mL (199.3 mM)
SMILES

Chemical Name: Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate

InChi Key: KJBLQGHJOCAOJP-UHFFFAOYSA-N

InChi Code: 1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2

SMILES Code: O.Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

Synonyms

AHR-3070-C, Metoclopramide HCl, Metoclopramide hydrochloride, Metoclopramide monohydrochloride monohydrate, Maxolon, AHR3070-C, AHR 3070-C, Metozolv, Reglan

实验参考方法
In Vitro

In vitro activity: Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

In Vivo
Animal model
Formulation & Dosage
References