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Doxylamine Succinate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxylamine Succinate图片
CAS NO:562-10-7
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议
5g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)388.46
FormulaC17H22N2O.C4H6O4
CAS No.562-10-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 78 mg/mL (200.8 mM)
Water: 78 mg/mL (200.8 mM)
Ethanol:
Solubility (In vivo)

Chemical Name: butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine

InChi Key: KBAUFVUYFNWQFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

SMILES Code: CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O

Synonyms

Doxylamine Succinate; Decapryn; Unisom; Evigoa D

实验参考方法
In Vitro

In vitro activity: The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum thyroid hormone levels are examined in B6C3F1 mice following dietary exposure for 7 or 15 days (0, 40, 375, 750, or 1500 ppm in diet, expressed as free base doxylamine). The results suggest that doxylamine is a phenobarbital-type inducer of liver microsomal cytochrome P450 in B6C3F1 mice, and consistent with the hypothesis that doxylamine increases the activity of those hepatic enzymes involved in T4 metabolism.

In Vivo
Animal model
Formulation & Dosage
References

Toxicol Appl Pharmacol. 1996 Dec;141(2):584-94.