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Tripelennamine HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tripelennamine HCl图片
CAS NO:154-69-8
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)291.82
FormulaC16H21N3.HCl
CAS No.154-69-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 2 mg/mL (6.9 mM)
Water: 58 mg/mL (198.75 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: N,N-dimethyl-N-(phenylmethyl)-N-pyridin-2-ylethane-1,2-diamine hydrochloride

InChi Key: FSSICIQKZGUEAE-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

SMILES Code: CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2.[H]Cl

SynonymsPyribenzamine HCl; Piristin; Pyrinamine; Stanzamine; Tripelennamine; Pyribenzamine.
实验参考方法
In Vitro

In vitro activity: Tripelennamine is a substrate for a tertiary amine UDP-glucuronosyltransferases which catalyzes the formation of quaternary ammonium-linked glucuronides. Tripelennamine inhibits the glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by a mixture of competitive and noncompetitive inhibition in both human and rabbit liver microsomes. Vibrations of the aminopyridine chromophore in Tripelennamine at neutral pH, where the aminoalkyl chain is protonated, are modified when compared to the vibrational pattern recorded for a fully neutral molecule in alkaline solution.

In VivoTripelennamine HCl (i.v.) causes central nervous system (CNS) excitement in standing horses, and the horses became very alert, agitated, and uncomfortable, as indicated by their raising the head and tightening the neck muscles, excessive rapid movements of eyes and ears, biting, snorting, briskly swishing the tail, and stomping and pawing with front feet. Accordingly, hemoglobin concentration of standing horses increase significantly after Tripelennamine HCl treatment. Tripelennamine HCl (i.v.) significantly increases mixed venous blood O2 tension and hemoglobin-O2 saturation in standing horse, as well as arterial and mixed-venous blood O2 contents, but the arterial-to-mixed-venous O2 content gradient of standing horses is not significantly affected. Tripelennamine HCl (0.5 mg/kg i.v.) administrated both in horses and camels results in the terminal elimination half-lives of 2.39 and 2.08 hours, total body clearances of 0.97 and 0.84 L/h/kg. The volumes of distribution at steady state are 2.87 and 1.69 L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model are 1.75 and 1.06 L/kg .
Animal modelHorses
Formulation & Dosage0.5 mg/kg i.v.
References

Chem Res Toxicol. 1993 Nov-Dec;6(6):846-51; J Appl Physiol (1985). 2002 Apr;92(4):1515-23.