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Pemirolast potassium(TWT-8152 BMY 26517)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pemirolast potassium(TWT-8152 BMY 26517)图片
CAS NO:100299-08-9
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)266.3
FormulaC10H7N6O.K
CAS No.100299-08-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 53 mg/mL (199.0 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: potassium 5-(9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)tetrazol-1-ide

InChi Key: NMMVKSMGBDRONO-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1

SMILES Code: O=C1C(C2=NN=NN2[K])=CN=C3N1C=CC=C3C

Synonyms

TWT-8152; BMY 26517; TWT 8152; BMY 26517; TWT8152; BMY 26517; Pemirolast; Pemirolast potassium. trade name: Alegysal and Alamast.

实验参考方法
In Vitro

In vitro activity: Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel.

In VivoPemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats.
Animal modelRats
Formulation & Dosage
References

Ann Allergy. 1992 Jun;68(6):488-91; Eur J Pharmacol. 2011 Jul 1;661(1-3):57-62.